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repertorios de anticuerpos en muestras de sangre extra de 17 voluntarios humanos quienes fueron inmunizados con vacunas contra la influenza de temporada de 2009 y 2010. Estos voluntarios fueron reclutados de tres grupos de diferentes edades: ni de ocho a 17 a j adultos de 18 a 30 a e individuos ancianos de entre 70 y 100 a de edad. Tomando ventaja de la tecnolog de secuenciaci de ADN de alto rendimiento, los investigadores fueron capaces de llevar a cabo "un conteo de cabezas" de los anticuerpos en el pico de la respuesta inmunol de los voluntarios hacia la vacuna contra la influenza. Ellos notaron diferencias significativas en la composici de los anticuerpos respondiendo a la vacuna entre los diversos grupos de edades distintas. Despu de contar los anticuerpos, Jiang y colegas empezaron a comparar y agrupar anticuerpos que posiblemente evolucionaron a partir del mismo ancestro. Ellos descubrieron que el n de distintos tipos de anticuerpos en el sistema inmunol se reduce con la

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